Structure of PDB 7qlq Chain AAA

Receptor sequence
>7qlqAAA (length=383) Species: 511145 (Escherichia coli str. K-12 substr. MG1655) [Search protein sequence]
ANRMILNETAWFGRGAVGALTDEVKRRGYQKALIVTDKTLVQCGVVAKVT
DKMDAAGLAWAIYDGVVPNPTITVVKEGLGVFQNSGADYLIAIGGGSPQD
TCKAIGIISNNPEFADVRSLEGLSPTNKPSVPILAIPTTAGTAAEVTIGY
VITDEEKRRKFVCVDPHDIPQVAFIDADMMDGMPPALKAATGVDALTHAI
EGYITRGAWALTDALHIKAIEIIAGALRGSVAGDKDAGEEMALGQYVAGM
GFSNVGVGLVHGMAHPLGAFYNTPHGVANAILLPHVMRYNADFTGEKYRD
IARVMGVKVEGMSLEEARNAAVEAVFALNRDVGIPPHLRDVGVRKEDIPA
LAQAALDDVCTGGNPREATLEDIVELYHTAWTS
3D structure
PDB7qlq Crystal structures and kinetic studies of a laboratory evolved aldehyde reductase explain the dramatic shift of its new substrate specificity.
ChainAAA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.77: lactaldehyde reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 E9I AAA G151 V166 H200 F254 S255 H263 C362 G149 V164 H198 F252 S253 H261 C360
BS02 APR AAA D39 T41 L42 G97 G98 S99 T140 T141 T144 K162 G184 M185 L189 H277 D37 T39 L40 G95 G96 S97 T138 T139 T142 K160 G182 M183 L187 H275
BS03 FE AAA D196 H200 H263 H277 D194 H198 H261 H275
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004022 alcohol dehydrogenase (NAD+) activity
GO:0008198 ferrous iron binding
GO:0008912 lactaldehyde reductase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0052660 R-lactaldehyde reductase activity
GO:0052661 S-lactaldehyde reductase activity
Biological Process
GO:0006004 fucose metabolic process
GO:0019301 rhamnose catabolic process
GO:0019317 fucose catabolic process
GO:0042355 L-fucose catabolic process
GO:0042846 glycol catabolic process
GO:0051143 propanediol metabolic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7qlq, PDBe:7qlq, PDBj:7qlq
PDBsum7qlq
PubMed37261425
UniProtP0A9S1|FUCO_ECOLI Lactaldehyde reductase (Gene Name=fucO)

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