Structure of PDB 7ou8 Chain AAA

Receptor sequence
>7ou8AAA (length=714) Species: 226186 (Bacteroides thetaiotaomicron VPI-5482) [Search protein sequence]
VSLQPPPQQLIVQNKTIDLPAVYQLNGGEEANPHAVKVLKELLSGKQSSK
KGMLISIGEKGDKSVRKYSRQIPDHKEGYYLSVNEKEIVLAGNDERGTYY
ALQTFAQLLKDGKLPEVEIKDYPSVRYRGVVEGFYGTPWSHQARLSQLKF
YGKNKMNTYIYGPKDDPYHSAPNWRLPYPDKEAAQLQELVAVANENEVDF
VWAIHPGQDIKWNKEDRDLLLAKFEKMYQLGVRSFAVFFDDISGEGTNPQ
KQAELLNYIDEKFAQVKPDINQLVMCPTEYNKSWSNPNGNYLTTLGDKLN
PSIQIMWTGDRVISDITRDGISWINERIKRPAYIWWNFPVSDYVRDHLLL
GPVYGNDTTIAKEMSGFVTNPMEHAESSKIAIYSVASYAWNPAKYDTWQT
WKDAIRTILPSAAEELECFAMHNSDLGPNGHGYRREESMDIQPAAERFLK
AFKEGKNYDKADFETLQYTFERMKESADILLMNTENKPLIVEITPWVHQF
KLTAEMGEEVLKMVEGRNESYFLRKYNHVKALQQQMFYIDQTSNQNPYQP
GVKTATRVIKPLIDRTFATVVKFFNQKFNAHLDATTDYMPHKMISNVEQI
KNLPLQVKANRVLISPANEVVKWAAGNSVEIELDAIYPGENIQINFGKDA
PCTWGRLEISTDGKEWKTVDLKQKESRLSAGLQKAPVKFVRFTNVSDEEQ
QVYLRQFVLTIEKK
3D structure
PDB7ou8 Bicyclic Picomolar OGA Inhibitors Enable Chemoproteomic Mapping of Its Endogenous Post-translational Modifications
ChainAAA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.169: protein O-GlcNAcase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 1XI AAA Y137 K166 D242 D243 Y282 V314 W337 N339 D344 H433 Y135 K164 D240 D241 Y280 V312 W335 N337 D342 H431
External links
PDB RCSB:7ou8, PDBe:7ou8, PDBj:7ou8
PDBsum7ou8
PubMed
UniProtQ89ZI2|OGA_BACTN O-GlcNAcase BT_4395 (Gene Name=BT_4395)

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