Structure of PDB 7olj Chain AAA

Receptor sequence
>7oljAAA (length=161) Species: 9606 (Homo sapiens) [Search protein sequence]
GSGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQK
VCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHA
YIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFC
RVTLGKSFLQF
3D structure
PDB7olj Analogs of TIQ-A as inhibitors of human mono-ADP-ribosylating PARPs.
ChainAAA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VJN AAA H1031 G1032 Y1050 Y1060 A1062 K1067 S1068 Y1071 H82 G83 Y101 Y111 A113 K118 S119 Y122
BS02 ZN AAA C1081 H1084 C1089 C1092 C132 H135 C140 C143
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7olj, PDBe:7olj, PDBj:7olj
PDBsum7olj
PubMed34801828
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

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