Structure of PDB 7oho Chain AAA

Receptor sequence
>7ohoAAA (length=605) Species: 10116 (Rattus norvegicus) [Search protein sequence]
GMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKY
VCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTEKQIGYLFISVLVNSNSEL
IRLINNAIKNDLASRNPTFMGLALHCIANVGSREMAEAFAGEIPKILVAG
DTMDSVKQSAALCLLRLYRTSPDLVPMGDWTSRVVHLLNDQHLGVVTAAT
SLITTLAQKNPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLS
VKLLRLLQCYPPPEDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNA
VLFEAISLIIHHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLAS
SEFSHEAVKTHIETVINALKTERDVSVRQRAVDLLYAMCDRSNAQQIVAE
MLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDTILNLIRIAGDYVS
EEVWYRVIQIVINRDDVQGYAAKTVFEALQAPACHENLVKVGGYILGEFG
NLIAGDPRSSPLIQFNLLHSKFHLCSVPTRALLLSTYIKFVNLFPEVKAT
IQDVLRSDSQLKNADVELQQRAVEYLRLSTVASTDILATVLEEMPPFPER
ESSIL
3D structure
PDB7oho FCHO controls AP2's initiating role in endocytosis through a PtdIns(4,5)P 2 -dependent switch.
ChainAAA
Resolution2.88 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IHP AAA R11 G12 Y53 K57 Y58 K61 R3 G4 Y45 K49 Y50 K53
Gene Ontology
Biological Process
GO:0006886 intracellular protein transport
GO:0016192 vesicle-mediated transport
Cellular Component
GO:0005794 Golgi apparatus
GO:0030117 membrane coat
GO:0030121 AP-1 adaptor complex

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Biological Process
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Cellular Component
External links
PDB RCSB:7oho, PDBe:7oho, PDBj:7oho
PDBsum7oho
PubMed35486718
UniProtP18484|AP2A2_RAT AP-2 complex subunit alpha-2 (Gene Name=Ap2a2)

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