Structure of PDB 7nb2 Chain AAA

Receptor sequence
>7nb2AAA (length=347) Species: 9606 (Homo sapiens) [Search protein sequence]
PEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGLSNMLFQCSLPDT
TATPRKVLLRLYGAEAMVLESVMFAILAERSLGPKLYGIFPQGRLEQFIP
SRRLDTEELSLPDISAEIAEKMATFHGMKMPFNKEPKWLFGTMEKYLKEV
LRIKFTEESRIKKLHKLLSYNLPLELENLRSLLESTPSPVVFCHNDCQEG
NILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYP
FFRANIRKYPTKKQQLHFISSYLPAFQNDFENLSTEEKSIIKEEMLLEVN
RFALASHFLWGLWSIVQAKISSIEFGYMDYAQARFDAYFHQKRKLGV
3D structure
PDB7nb2 Identification of unprecedented ATP-competitive choline kinase inhibitors.
ChainAAA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.32: choline kinase.
2.7.1.82: ethanolamine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U6E AAA L144 P194 E206 F208 I209 S211 R213 L58 P84 E96 F98 I99 S101 R103
BS02 MG AAA E309 E349 Y352 E199 E239 Y242
External links
PDB RCSB:7nb2, PDBe:7nb2, PDBj:7nb2
PDBsum7nb2
PubMed34416377
UniProtP35790|CHKA_HUMAN Choline kinase alpha (Gene Name=CHKA)

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