Structure of PDB 7n7x Chain AAA

Receptor sequence
>7n7xAAA (length=229) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGTESSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLP
LQDVWRIYSGILELSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQ
APLEYTEFQKPISLPIYTNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEE
CQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITS
WGEGCARREQPGVYTKVAEYMDWILEKTQ
3D structure
PDB7n7x Berotralstat (BCX7353): Structure-Guided Design of a Potent, Selective, and Oral Plasma Kallikrein Inhibitor to Prevent Attacks of Hereditary Angioedema (HAE).
ChainAAA
Resolution2.097 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.34: plasma kallikrein.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0RI AAA H44 G90 D93 Y242 D259 A260 C261 K262 S284 W285 G286 E287 G288 C289 H44 G90 D93 Y158 D175 A176 C177 K178 S200 W201 G202 E203 G204 C205 BindingDB: Ki=25.1nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7n7x, PDBe:7n7x, PDBj:7n7x
PDBsum7n7x
PubMed34436898
UniProtP03952|KLKB1_HUMAN Plasma kallikrein (Gene Name=KLKB1)

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