Structure of PDB 7akr Chain AAA

Receptor sequence

>7akrAAA (length=344) Species: 9606 (Homo sapiens) [Search protein sequence]

SSLSRFRGCLAGALLGDCVGSFYAAHDTVDLTSVLRHVQSLEPDPGTPGS
ERTEALYYTDDTAMARALVQSLLAKEAFDEVDMAHRFAQEYKKDPDRGYG
AGVVTVFKKLLNPKCRDVFEPARAQFNGKGSYGNGGAMRVAGISLAYSSV
QDVQKFARLSAQLTHASSLGYNGAILQALAVHLALQGESSSEHFLKQLLG
HMEDLEGDAQSVLDARELGMEERPYSSRLKKIGELLDQASVTREEVVSEL
GNGIAAFESVPTAIYCFLRCMEPDPEIPSAFNSLQRTLIYSISLGGDTDT
IATMAGAIAGAYYGMDQVPESWQQSCEGYEETDILAQSLHRVFQ

3D structure

PDB

7akr Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal.

Chain

AAA

Resolution

1.95 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.2.1.143: poly(ADP-ribose) glycohydrolase.
3.2.2.-
3.5.1.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	MG	AAA	T76 D77 D78 D316	T59 D60 D61 D299
BS02	MG	AAA	D314 D316 T317	D297 D299 T300
BS03	AR6	AAA	D77 D78 G117 A118 G119 V120 F143 S148 Y149 G150 N151 G152 H182 I271 D314 D316 T317	D60 D61 G100 A101 G102 V103 F126 S131 Y132 G133 N134 G135 H165 I254 D297 D299 T300
BS04	AR6	AAA	G115 Y116 I271	G98 Y99 I254

Gene Ontology

	Molecular Function
GO:0000287	magnesium ion binding
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004649	poly(ADP-ribose) glycohydrolase activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0046872	metal ion binding
GO:0061463	O-acetyl-ADP-ribose deacetylase activity
GO:0140292	ADP-ribosylserine hydrolase activity

	Biological Process
GO:0006281	DNA repair
GO:0006287	base-excision repair, gap-filling
GO:0060546	negative regulation of necroptotic process
GO:0071451	cellular response to superoxide
GO:0140290	peptidyl-serine ADP-deribosylation

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005694	chromosome
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0016604	nuclear body
GO:0090734	site of DNA damage

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Molecular Function

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Cellular Component

External links

PDB	RCSB:7akr, PDBe:7akr, PDBj:7akr
PDBsum	7akr
PubMed	34321462
UniProt	Q9NX46\|ADPRS_HUMAN ADP-ribosylhydrolase ARH3 (Gene Name=ADPRS)

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