Structure of PDB 6zj1 Chain AAA

Receptor sequence

>6zj1AAA (length=362) Species: 9606 (Homo sapiens) [Search protein sequence]

LNNYLHVFYYSWYGNPQFDGKYIHWNHPVLEHWDPRIAKNYPQGRHNPPD
DIGSSFYPELGSYSSRDPSVIETHMRQMRSASIGVLALSWYPPDVNDENG
EPTDNLVPTILDKAHKYNLKVTFHIEPYSNRDDQNMYKNVKYIIDKYGNH
PAFYRYKTKTGNALPMFYVYDSYITKPEKWANLLTTSGSRSIRNSPYDGL
FIALLVEEKHKYDILQSGFDGIYTYFATNGFTYGSSHQNWASLKLFCDKY
NLIFIPSVGPGYIDTSIRPWNTQNTRNRINGKYYEIGLSAALQTRPSLIS
ITSFNQWHEGTQIEKAVPKRTSNTVYLDYRPHKPGLYLELTRKWSEKYSK
ERATYALDRQLP

3D structure

PDB

6zj1 Structure of human endo-alpha-1,2-mannosidase (MANEA), an antiviral host-glycosylation target.

Chain

AAA

Resolution

1.957 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.2.1.130: glycoprotein endo-alpha-1,2-mannosidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	MMA	AAA	Y268 D269 Y271 V304 F324	Y170 D171 Y173 V206 F226
BS02	MAN	AAA	Y268 F324 Y360 R366 E407	Y170 F226 Y262 R268 E309
BS03	MAN	AAA	Y108 E224 Y268 Y323 Q404 E407	Y10 E126 Y170 Y225 Q306 E309
BS04	GLC	AAA	H125 D195 E196 N197 I365 R366 E407	H27 D97 E98 N99 I267 R268 E309
BS05	TEW	AAA	T256 K257 T258 A454 L455 D456	T158 K159 T160 A356 L357 D358
BS06	TEW	AAA	K309 F344 K347 Y348	K211 F246 K249 Y250

Gene Ontology

	Molecular Function
GO:0016798	hydrolase activity, acting on glycosyl bonds

View graph for
Molecular Function

External links

PDB	RCSB:6zj1, PDBe:6zj1, PDBj:6zj1
PDBsum	6zj1
PubMed	33154157
UniProt	Q5SRI9\|MANEA_HUMAN Glycoprotein endo-alpha-1,2-mannosidase (Gene Name=MANEA)

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