Structure of PDB 6zin Chain AAA

Receptor sequence
>6zinAAA (length=441) Species: 10116 (Rattus norvegicus) [Search protein sequence]
IYSKVLVTAIYLALFVVGTVGNGVTLFTLARKKSLQSLQSRVDYYLGSLA
LSDLLILLFALPVDLYNFIWVHHPWAFGDAGCKGYYFLREACTYATALNV
VSLSVELYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGL
QNLVCTPIVDTATLRVVIQLNTFMSFLFPMLVASILNTVAARRLTVMVHP
GRVQALRRGVLVLRAVVIAFVVCWLPYHVRRLMFVYITALFDFYHYFYML
SNALVYVSAAINPILYNLAEDLVEDWEKARKLLEAARKGQDDEVRILLAN
GADVNTADETGFTPLHLAAWEGHLGIVEVLLKNGADVNANDERGHTPLHL
AAYTGHLEIVEVLLKNGAGVNATDVIGTAPLHLAAMWGHLEIVEVLLKNG
ADVNAQDKFGKTPFDLAIDNGNEDIAEVLQKAATRELEVLF
3D structure
PDB6zin Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
ChainAAA
Resolution2.639 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Q6Q AAA Y146 R327 R328 M330 F331 I334 H348 Y351 Y86 R230 R231 M233 F234 I237 H245 Y248 BindingDB: Ki=2.6nM,IC50=82nM
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0016492 G protein-coupled neurotensin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6zin, PDBe:6zin, PDBj:6zin
PDBsum6zin
PubMed33571132
UniProtP20789|NTR1_RAT Neurotensin receptor type 1 (Gene Name=Ntsr1)

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