Structure of PDB 6zb3 Chain AAA

Receptor sequence

>6zb3AAA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]

SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE

3D structure

PDB

6zb3 The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor.

Chain

AAA

Resolution

1.419 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	QCZ	AAA	W81 P82 L94 Y139 N140 I146 M149	W40 P41 L53 Y98 N99 I105 M108	BindingDB: IC50=79nM

External links

PDB	RCSB:6zb3, PDBe:6zb3, PDBj:6zb3
PDBsum	6zb3
PubMed	32702236
UniProt	O60885\|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

[Back to BioLiP]