Structure of PDB 6zb1 Chain AAA

Receptor sequence

>6zb1AAA (length=112) Species: 9606 (Homo sapiens) [Search protein sequence]

GKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHP
MDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQ
DVFEFRYAKMPD

3D structure

PDB

6zb1 The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor.

Chain

AAA

Resolution

1.6 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	QCZ	AAA	W370 L383 Y428 N429 P430 V435	W27 L40 Y85 N86 P87 V92	BindingDB: IC50=25119nM

External links

PDB	RCSB:6zb1, PDBe:6zb1, PDBj:6zb1
PDBsum	6zb1
PubMed	32702236
UniProt	P25440\|BRD2_HUMAN Bromodomain-containing protein 2 (Gene Name=BRD2)

[Back to BioLiP]