Structure of PDB 6zb0 Chain AAA

Receptor sequence

>6zb0AAA (length=115) Species: 9606 (Homo sapiens) [Search protein sequence]

GSMGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDII
KHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMAR
KLQDVFEFRYAKMPD

3D structure

PDB

6zb0 The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor.

Chain

AAA

Resolution

1.613 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	QCW	AAA	W370 N429 V435	W30 N89 V95	BindingDB: IC50=15849nM

External links

PDB	RCSB:6zb0, PDBe:6zb0, PDBj:6zb0
PDBsum	6zb0
PubMed	32702236
UniProt	P25440\|BRD2_HUMAN Bromodomain-containing protein 2 (Gene Name=BRD2)

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