Structure of PDB 6z84 Chain AAA

Receptor sequence
>6z84AAA (length=326) Species: 9606 (Homo sapiens) [Search protein sequence]
GPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSE
VFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVK
DRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHR
DVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVD
YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLY
DYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLL
RYDHQSRLTAREAMEHPYFYTVVKDQ
3D structure
PDB6z84 Development of a potent and selective chemical probe for the pleiotropic kinase CK2.
ChainAAA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D156 K158 N161 D175 S194
Catalytic site (residue number reindexed from 1) D151 K153 N156 D170 S189
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QB8 AAA V53 K68 F113 V116 N118 M163 D175 V51 K66 F108 V111 N113 M158 D170 BindingDB: IC50=10.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6z84, PDBe:6z84, PDBj:6z84
PDBsum6z84
PubMed33484635
UniProtP68400|CSK21_HUMAN Casein kinase II subunit alpha (Gene Name=CSNK2A1)

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