Structure of PDB 6z4v Chain AAA

Receptor sequence
>6z4vAAA (length=456) Species: 10116 (Rattus norvegicus) [Search protein sequence]
NSDLDVNTDIYSKVLVTAIYLALFVVGTVGNGVTLFTLARKRVDYYLGSL
ALSDLLILLFALPVELYNFIWVHHPWAFGDAGCKGYYFLRDACTYATALN
VVSLSVELYLAICRTKKFISAIWLASALLAIPMLFTMGLQNLSGDGTHPG
GLVCTPIVDTATLRVVIQLNTFMSFLFPMLVASILNTVAARRLTVMVHQA
AFNMTIEPGRVQALRRGVLVLRAVVIAFVVCWLPYHVRRLMFVYISDEQW
TTALFDFYHYFYMLSNALFYVSSAINPILYNLAEDLVEDWEKARKLLEAA
RKGQDDEVRILLANGADVNTADETGFTPLHLAAWEGHLGIVEVLLKNGAD
VNANDERGHTPLHLAAYTGHLEIVEVLLKNGAGVNATDVIGTAPLHLAAM
WGHLEIVEVLLKNGADVNAQDKFGKTPFDLAIDNGNEDIAEVLQKAATRE
LEVLFQ
3D structure
PDB6z4v Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
ChainAAA
Resolution2.595 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide AAA L55 F128 H132 Y146 V224 T226 R327 R328 F331 S335 W339 F344 Y347 L4 F69 H73 Y87 V153 T155 R238 R239 F242 S246 W250 F255 Y258
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0016492 G protein-coupled neurotensin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6z4v, PDBe:6z4v, PDBj:6z4v
PDBsum6z4v
PubMed33571132
UniProtP20789|NTR1_RAT Neurotensin receptor type 1 (Gene Name=Ntsr1)

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