Structure of PDB 6vgs Chain AAA

Receptor sequence

>6vgsAAA (length=539) Species: 1360 (Lactococcus lactis subsp. lactis) [Search protein sequence]

MYTVGDYLLDRLHELGIEEIFGVPGDYNLQFLDHIISRKDMKWVGNANEL
NASYMADGYARTKKAAAFLTTFGVGELSAVNGLAGSYAENLPVVEIVGSP
TSKVQNEGKFVHHTLADGDFKHFMKMHEPVTAARTLLTAENATVEIDRVL
SALLKERKPVYINLPVDVAAAKAEKPSLPLKNTSDQEILNKIQESLKNAK
KPIVITGHEIISFGLEKTVSQFISKTKLPITTLNFGKSSVDEALPSFLGI
YNGKLSEPNLKEFVESADFILMLGVKLTDSSTGVFTHHLNENKMISLNID
EGKIFNESIQNFDFESLISSLLDLSEIEYKGKYIDKDFVPSNALLSQDRL
WQAVENLTQSNETIVAEQGTSFFGASPIFLKPKSHFIGQPLWGSIGYTFP
AALGSQIADKESRHLLFIGDGSLQLTVQELGLAIREKINPICFIINNDGY
TVEREIHGPNQSYNDIPMWNYSKLPESFGATEERVVSKIVRTENEFVSVM
KEAQADPNRMYWIELILAKEDAPKVLKKMGKLFAEQNKS

3D structure

PDB

6vgs Isobutanol production freed from biological limits using synthetic biochemistry.

Chain

AAA

Resolution

1.8 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	V23 G25 D26 Y27 N28 E49 T71 H112 H113 L115 A116 V166 S287 Q377 G402 I404 D429 N456 G458 Y459 V461 E462
Catalytic site (residue number reindexed from 1)	V23 G25 D26 Y27 N28 E49 T71 H112 H113 L115 A116 V166 S281 Q368 G393 I395 D420 N447 G449 Y450 V452 E453
Enzyme Commision number	?

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	MG	AAA	D429 N456 G458	D420 N447 G449
BS02	TPP	AAA	T379 G402 S403 I404 G428 G430 S431 N456 G458 Y459 T460 V461 E462	T370 G393 S394 I395 G419 G421 S422 N447 G449 Y450 T451 V452 E453
BS03	TPP	AAA	P24 E49 V74	P24 E49 V74

Gene Ontology

	Molecular Function
GO:0000287	magnesium ion binding
GO:0003824	catalytic activity
GO:0004737	pyruvate decarboxylase activity
GO:0016831	carboxy-lyase activity
GO:0030976	thiamine pyrophosphate binding
GO:0046872	metal ion binding

	Biological Process
GO:0000949	aromatic amino acid family catabolic process to alcohol via Ehrlich pathway

	Cellular Component
GO:0005829	cytosol

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6vgs, PDBe:6vgs, PDBj:6vgs
PDBsum	6vgs
PubMed	32855421
UniProt	A0A0B8QZ66

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