Structure of PDB 6tw7 Chain AAA

Receptor sequence

>6tw7AAA (length=411) Species: 5664 (Leishmania major)

AHAFWSTQPVPQTEDETEKIVFAGPMDEPKTVADIPEEPYPIASTFEWWT
PNMEAADDIHAIYELLRDNYVEDDDSMFRFNYSEEFLQWALCPPNYIPDW
HVAVRRKADKKLLAFIAGVPVTLRMGTPKYMKVKAQEKGEGEEAAKYDEP
RHICEINFLCVHKQLREKRLAPILIKEATRRVNRTNVWQAVYTAGVLLPT
PYASGQYFHRSLNPEKLVEIRFSGIPAQYQKFQNPMAMLKRNYQLPSAPK
NSGLREMKPSDVPQVRRILMNYLDSFDVGPVFSDAEISHYLLPRDGVVFT
YVVENDKKVTDFFSFYRIPSTVIGNSNYNLLNAAYVHYYAATSIPLHQLI
LDLLIVAHSRGFDVCNMVEILDNRSFVEQLKFGAGDGHLRYYFYNWAYPK
IKPSQVALVML

3D structure

• PDB: 6tw7 Leishmania major N-myristoyltransferase in complex with indazole inhibitor IMP-918
• Chain: AAA
• Resolution: 1.4 Å

Enzymatic activity

• Enzyme Commision number: 2.3.1.97: glycylpeptide N-tetradecanoyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MYA	AAA	H12 F14 W15 Y80 V81 L169 C170 V171 R176 E177 R179 A181 T189 V192 A200 Y202 T203 L208 Y404	H2 F4 W5 Y70 V71 L159 C160 V161 R166 E167 R169 A171 T179 V182 A190 Y192 T193 L198 Y394
BS02	MG	AAA	L175 K178 L180	L165 K168 L170
BS03	NZB	AAA	V81 E82 D83 F90 T203 Y217 N376 M377 L421	V71 E72 D73 F80 T193 Y207 N366 M367 L411

Gene Ontology

Molecular Function

• GO:0004379 glycylpeptide N-tetradecanoyltransferase activity
• GO:0016746 acyltransferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006499 N-terminal protein myristoylation

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6tw7, PDBe:6tw7, PDBj:6tw7
• PDBsum: 6tw7
• UniProt: Q4Q5S8