Structure of PDB 6tw6 Chain AAA

Receptor sequence

>6tw6AAA (length=385) Species: 126793 (Plasmodium vivax Sal-1)

MDYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYV
CDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTW
HIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLA
PVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIG
FSSLNSRLTMSRAIKLYRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQF
NLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGND
KYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSV
FEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL

3D structure

• PDB: 6tw6 Plasmodium vivax N-myristoyltransferase with bound indazole inhibitor IMP-923
• Chain: AAA
• Resolution: 1.7 Å

Enzymatic activity

• Enzyme Commision number: 2.3.1.97: glycylpeptide N-tetradecanoyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NHW	AAA	Y28 F30 W31 Y95 V96 V160 L163 C164 V165 R170 S171 R173 A175 T183 I186 W192 A194 Y196 T197 A198 L202 Y393	Y3 F5 W6 Y70 V71 V135 L138 C139 V140 R145 S146 R148 A150 T158 I161 W167 A169 Y171 T172 A173 L177 Y368
BS02	NZE	AAA	F105 T197 Y211 Y334 L388 L410	F80 T172 Y186 Y309 L363 L385
BS03	MG	AAA	K172 L174	K147 L149

Gene Ontology

Molecular Function

• GO:0004379 glycylpeptide N-tetradecanoyltransferase activity
• GO:0016746 acyltransferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006499 N-terminal protein myristoylation
• GO:0018008 N-terminal peptidyl-glycine N-myristoylation

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6tw6, PDBe:6tw6, PDBj:6tw6
• PDBsum: 6tw6
• UniProt: A5K1A2