Structure of PDB 6tpz Chain AAA

Receptor sequence

>6tpzAAA (length=125) Species: 9606 (Homo sapiens) [Search protein sequence]

SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPT

3D structure

PDB

6tpz Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening.

Chain

AAA

Resolution

1.299 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NV2	AAA	W81 P82 F83 V87 L92 Y139 N140 I146	W40 P41 F42 V46 L51 Y98 N99 I105	BindingDB: IC50=13nM,Kd=5.0nM

External links

PDB	RCSB:6tpz, PDBe:6tpz, PDBj:6tpz
PDBsum	6tpz
PubMed	31904959
UniProt	O60885\|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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