Structure of PDB 6tpy Chain AAA

Receptor sequence

>6tpyAAA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]

SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE

3D structure

PDB

6tpy Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening.

Chain

AAA

Resolution

1.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NUB	AAA	W81 F83 L92 Y139 N140 I146	W40 F42 L51 Y98 N99 I105	BindingDB: IC50=79nM

External links

PDB	RCSB:6tpy, PDBe:6tpy, PDBj:6tpy
PDBsum	6tpy
PubMed	31904959
UniProt	O60885\|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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