Structure of PDB 6tpx Chain AAA

Receptor sequence

>6tpxAAA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]

SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE

3D structure

PDB

6tpx Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening.

Chain

AAA

Resolution

1.48 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NUW	AAA	W81 P82 F83 L92 Y139 N140 D145 I146	W40 P41 F42 L51 Y98 N99 D104 I105	BindingDB: IC50=251nM

External links

PDB	RCSB:6tpx, PDBe:6tpx, PDBj:6tpx
PDBsum	6tpx
PubMed	31904959
UniProt	O60885\|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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