Structure of PDB 6tkm Chain AAA

Receptor sequence
>6tkmAAA (length=206) Species: 9606 (Homo sapiens) [Search protein sequence]
GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVC
NKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYI
GGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRV
TLGKSFLQFMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITY
QIMRPE
3D structure
PDB6tkm Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor.
ChainAAA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NG5 AAA H1031 S1033 F1035 A1038 G1043 F1044 D1045 H1048 I1059 Y1060 Y1071 I1075 H80 S82 F84 A87 G92 F93 D94 H97 I108 Y109 Y120 I124 BindingDB: IC50=0.630000nM
BS02 ZN AAA C1081 H1084 C1089 C1092 C130 H133 C138 C141
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:6tkm, PDBe:6tkm, PDBj:6tkm
PDBsum6tkm
PubMed32511917
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

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