Structure of PDB 6tio Chain AAA

Receptor sequence

>6tioAAA (length=497) Species: 5061 (Aspergillus niger)

AQPAHLCFRSFVEALKVDNDLVEINTPIDPNLEAAAITRRVCETNDKAPL
FNNLIGMKNGLFRILGAPGSLRKSSADRYGRLARHLALPPTASMREILDK
MLSASDMPPIPPTIVPTGPCKENSLDDSEFDLTELPVPLIHKSDGGKYIQ
TYGMHIVQSPDGTWTNWSIARAMVHDKNHLTGLVIPPQHIWQIHQMWKKE
GRSDVPWALAFGVPPAAIMASSMPIPDGVTEAGYVGAMTGSSLELVKCDT
NDLYVPATSEIVLEGTLSISETGPEGPFGEMHGYIFPGDTHLGAKYKVNR
ITYRNNAIMPMSSCGRLTDETHTMIGSLAAAEIRKLCQQNDLPITDAFAP
FESQVTWVALRVDTEKLRAMKTTSEGFRKRVGDVVFNHKAGYTIHRLVLV
GDDIDVYEGKDVLWAFSTRCRPGMDETLFEDVRGFPLIPYMGHGNGPAHR
GGKVVSDALMPTEYTTGRNWEAADFNQSYPEDLKQKVLDNWTKMGFS

3D structure

• PDB: 6tio Enzymatic C-H activation of aromatic compounds through CO 2 fixation.
• Chain: AAA
• Resolution: 1.54 Å

Enzymatic activity

• Enzyme Commision number: 4.1.1.102: phenacrylate decarboxylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MN	AAA	N168 H191 E233	N166 H189 E231
BS02	FMN	AAA	N168 S170 I171 A172 R173 Q190 H191 S223 S224 M225 P226 I327 K391	N166 S168 I169 A170 R171 Q188 H189 S221 S222 M223 P224 I325 K389
BS03	ND8	AAA	R173 F280 E282 M283 F437 L439	R171 F278 E280 M281 F435 L437

Gene Ontology

Molecular Function

• GO:0016831 carboxy-lyase activity
• GO:0030145 manganese ion binding
• GO:0042802 identical protein binding
• GO:0046872 metal ion binding

Biological Process

• GO:0009074 aromatic amino acid family catabolic process
• GO:0018966 styrene metabolic process
• GO:0033494 ferulate metabolic process
• GO:0046281 cinnamic acid catabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:6tio, PDBe:6tio, PDBj:6tio
• PDBsum: 6tio
• PubMed: 32719558
• UniProt: A2QHE5|FDC1_ASPNC Ferulic acid decarboxylase 1 (Gene Name=fdc1)