Structure of PDB 6t8v Chain AAA

Receptor sequence
>6t8vAAA (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]
SLCGMVWRKGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHC
FTVDDKEHSIKVSVGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDV
ALIKLKNKLKYGQTIRPICLPCTEGTTRALRLPPTTTCQQQKEELLPAQD
IKALFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVT
PRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKN
QKRQKQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL
3D structure
PDB6t8v Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.
ChainAAA
Resolution2.29 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.47: alternative-complement-pathway C3/C5 convertase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MVK AAA P172D T190 C191 R192 S195 W215 G216 V218 D218A N220B P187 T217 C218 R219 S222 W242 G243 V245 D246 N250
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006956 complement activation
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6t8v, PDBe:6t8v, PDBj:6t8v
PDBsum6t8v
PubMed32073845
UniProtP00751|CFAB_HUMAN Complement factor B (Gene Name=CFB)

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