Structure of PDB 6qsx Chain AAA

Receptor sequence
>6qsxAAA (length=285) Species: 9606 (Homo sapiens) [Search protein sequence]
SLCGMVWGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFT
VDDKEHSIKVSVGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVAL
IKLKNKLKYGQTIRPICLPCTEGTTRALRLPPTTTCQQQKEELLPAQDIK
ALFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPR
FLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQK
RQKQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL
3D structure
PDB6qsx Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.
ChainAAA
Resolution1.77 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.47: alternative-complement-pathway C3/C5 convertase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JGN AAA P172D Y172F T190 C191 R192 S195 S214 W215 G216 V218 D218A P185 Y187 T215 C216 R217 S220 S239 W240 G241 V243 D244 BindingDB: IC50=3350nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006956 complement activation
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6qsx, PDBe:6qsx, PDBj:6qsx
PDBsum6qsx
PubMed30926668
UniProtP00751|CFAB_HUMAN Complement factor B (Gene Name=CFB)

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