Structure of PDB 7qns Chain AA

Receptor sequence
>7qnsAA (length=222) Species: 9606 (Homo sapiens) [Search protein sequence]
DLPKSVDWRKKGYVTPVKNQKQCGSSWAFSATGALEGQMFRKTGKLVSLS
EQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICK
YRPENSVAQDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKS
GIYFEPDCSSKNLDHGVLVVGYGFEGANSQNSKYWLVKNSWGPEWGSNGY
VKIAKDKNNHCGIATAASYPNV
3D structure
PDB7qns Peptide VYEKKP in complex with human cathepsin V C25S mutant
ChainAA
Resolution1.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.43: cathepsin V.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide AA F147 Y148 K149 S150 I152 G196 F147 Y148 K149 S150 I152 G196
BS02 peptide AA G24 S26 G68 G69 F70 A137 D164 H165 G24 S26 G68 G69 F70 A137 D164 H165
BS03 TFA AA E121 K122 K183 K205 D206 E121 K122 K183 K205 D206
BS04 TFA AA R9 S197 Y200 R9 S197 Y200
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7qns, PDBe:7qns, PDBj:7qns
PDBsum7qns
PubMed
UniProtO60911|CATL2_HUMAN Cathepsin L2 (Gene Name=CTSV)

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