Structure of PDB 7q8m Chain AA

Receptor sequence
>7q8mAA (length=222) Species: 9606 (Homo sapiens) [Search protein sequence]
DLPKSVDWRKKGYVTPVKNQKQCGSAWAFSATGALEGQMFRKTGKLVSLS
EQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICK
YRPENSVAQDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKS
GIYFEPDCSSKNLDHGVLVVGYGFEGANSQNSKYWLVKNSWGPEWGSNGY
VKIAKDKNNHCGIATAASYPNV
3D structure
PDB7q8m Proteomic data and structure analysis combined reveal interplay of structural rigidity and flexibility on selectivity of cysteine cathepsins.
ChainAA
Resolution1.57 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.22.43: cathepsin V.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide AA G24 A26 W27 Q64 N67 G68 G69 F70 D164 H165 G24 A26 W27 Q64 N67 G68 G69 F70 D164 H165
BS02 TFA AA R9 S197 R9 S197
BS03 TFA AA E121 K122 K183 K205 D206 E121 K122 K183 K205 D206
BS04 TFA AA F70 M71 A72 A216 F70 M71 A72 A216
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7q8m, PDBe:7q8m, PDBj:7q8m
PDBsum7q8m
PubMed37095140
UniProtO60911|CATL2_HUMAN Cathepsin L2 (Gene Name=CTSV)

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