Structure of PDB 7mpi Chain AA

Receptor sequence

>7mpiAA (length=247) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]

GRVIRNQRKGAGSIFTSHTRLRQGAAKLRTLDYAERHGYIRGIVKQIVHD
SGRGAPLAKVVFRDPYKYRLREEIFIANEGVHTGQFIYAGKKASLNVGNV
LPLGSVPEGTIVSNVEEKPGDRGALARASGNYVIIIGHNPDENKTRVRLP
SGAKKVISSDARGVIGVIAGGGRVDKPLLKAGRAFHKYRLKRNSWPKTRG
VAMNPVDHPHGGGNHQHIGKASTISRGAVSGQKAGLIAARRTGLLRG

3D structure

PDB

7mpi CryoEM structures of pseudouridine-free ribosome suggest impacts of chemical modifications on ribosome conformations.

Chain

Resolution

3.05 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	AA	R247 G248	R246 G247
BS02	rna	AA	G2 R3 V4 N7 Q8 R9 K10 G11 S14 I15 F16 T17 S18 H19 T20 R21 L22 R23 G25 A26 Y34 R37 H38 G39 Y40 I44 H50 S52 R54 R64 D65 Y67 K68 Y69 R70 L71 G85 Y89 K93 A94 S95 E118 K119 A125 L126 R128 A129 S130 N132 L150 P151 S152 K156 G173 R174 V175 K177 L179 L180 K181 A182 G183 A185 F186 H187 K188 R190 L191 R193 N194 W196 P197 K198 T199 R200 G201 V202 A203 M204 N205 V207 D208 H211 G214 N215 H216 Q217 H218 G220 K221 A222 S223 T224 I225 S226 R227 V230 S231 G232 Q233 K234 G236 I238 A239 A240 R241 R242 T243 G244 L245	G1 R2 V3 N6 Q7 R8 K9 G10 S13 I14 F15 T16 S17 H18 T19 R20 L21 R22 G24 A25 Y33 R36 H37 G38 Y39 I43 H49 S51 R53 R63 D64 Y66 K67 Y68 R69 L70 G84 Y88 K92 A93 S94 E117 K118 A124 L125 R127 A128 S129 N131 L149 P150 S151 K155 G172 R173 V174 K176 L178 L179 K180 A181 G182 A184 F185 H186 K187 R189 L190 R192 N193 W195 P196 K197 T198 R199 G200 V201 A202 M203 N204 V206 D207 H210 G213 N214 H215 Q216 H217 G219 K220 A221 S222 T223 I224 S225 R226 V229 S230 G231 Q232 K233 G235 I237 A238 A239 R240 R241 T242 G243 L244
BS03	MG	AA	K198 R200	K197 R199

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0019843	rRNA binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:0042273	ribosomal large subunit biogenesis
GO:1990145	maintenance of translational fidelity

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:1990904	ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7mpi, PDBe:7mpi, PDBj:7mpi
PDBsum	7mpi
PubMed	35489333
UniProt	P0CX45\|RL2A_YEAST Large ribosomal subunit protein uL2A (Gene Name=RPL2A)

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