Structure of PDB 7tbl Chain A5

Receptor sequence

>7tblA5 (length=1276) Species: 9606 (Homo sapiens)

DLPPVAKAAQVVNQTLQLDDSYPDLDSYCRPGASSDYEMQSSDSSWAPFH
VVRHHNIPDKVFEHLNAGEVFTKLGLFAEIGYAWASIDSSLFLWDYTHPN
PELIGYEEATHTITAVALVPPKPGVFVKTITHVLVVATTSEIILLGVSAT
PTPSGSKSLTLYSTRMSVHRGGSDVSFIVGTKDGRIFLGGESDTDIHEIF
YQQEERWFSSRCGKINHSHPFGSRQQEWLRGLYVDDTRNLLYSLSNRSTI
RTYHMEGPEKLTKVIEKDKTSCLRDFAHMADSSPLFTDKTNIVALSPIPA
TEASKLHLMALTDTGCRLFLSATSSASYTALAPQSMQLQFVKFPPRESPT
RIRTLSQLDKTSRALDPSALGFRFSPGYFFDVVRKHPNQDMLFVSAPDTG
RIKVTQPASALKYFEQGTWIELENGNRTIEIGLTTAPFAAAKQPLGFGNE
LAVQFDQVPGEFAVLTNTGVHIVRRRRLVDIFAKALGNCVSASDDALERE
VRKFINQYGRVETIAAALAVACGQGSDLMDRNTENLARAAFIEYGGQPRL
ASVRLSSRHDALALYLTRLVRTLWKAKVVQVDISSTIPTSKLVTIQENVE
RLRNFLEANKSTIQGLAPPDIANQKEHQALHALQKLMESISEGISFVLML
FDERVSDIYARLDAVSQQQLKDLTYEQLFSQTPGKELAKVLVKAIVNRNI
ASGANVETVADALRRRCGSFCSPDDVVTFKAQEQLQRASEQAHNSPVLRA
LLAESLRLFEQVAGSLTPANLTTAVEQMISLKYYAGAIQLCLTVAQQKDR
GNTALSWVNDGKPANDSRKKAFDERKICYNLIHQVLDKLESDFAGEPELV
DGRPTLAATKRMEAYNVVNDSSDEVFHFDMYEWYIEKGWTDRILSIDSPH
VITYLQRLAETDFRHAELLCRFYTTRSRFFEAAQVQTNLAKSDLNISLKD
RIILLSRAKGNASVNTIGISRQQQQQLNHEASELLEIAHIQDDLLERLVA
DPRIPEERKAEIEEFLDGPIRTLTDLFNDYADQANYYDLCLLIFHAADFH
NPRTIMDTWNNLINQSHFEAEQRREYWEIVQDLPDLPIAVIAEPPLPYVY
VSQQIQLIAHRTSLDSLIFPVNSLLPVVCAYAINNGQDASIGADPCWPIQ
LFLNLGVPHALMVQVLENVLDTQEAPFTGRRRKLVVQWIAMAVDMWVREV
ERRASMSEAVMGSWVSELLGRADQVLTQIAGTGATLRGGAASDAEEIASL
RRTVKGLKRSVDMLLGGEMARMSFFR

3D structure

• PDB: 7tbl Architecture of the cytoplasmic face of the nuclear pore.
• Chain: A5
• Resolution: 23.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A5	G178 V198 F199 V200 I203 L234 Y235 S236 R238 Q276	G105 V125 F126 V127 I130 L161 Y162 S163 R165 Q203
BS02	peptide	A5	L147 G148 L149 F150 I153 G154 Y155 A156 W157 L164 F165 L166 W167 P172 I177 G178 Y179 E180 A188 V189 A190 L207 V209 S221 A222 T223 P224 T225 S227 G228 S229 K230 S231 L232 T233 E527	L74 G75 L76 F77 I80 G81 Y82 A83 W84 L91 F92 L93 W94 P99 I104 G105 Y106 E107 A115 V116 A117 L134 V136 S148 A149 T150 P151 T152 S154 G155 S156 K157 S158 L159 T160 E430
BS03	peptide	A5	R1135 L1150 T1151 F1154 N1155 D1159 Q1160 A1161	R1008 L1023 T1024 F1027 N1028 D1032 Q1033 A1034

Gene Ontology

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UnboundLocalError

Python 3.6.8: /usr/bin/python3 Mon Nov 25 22:35:50 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1443                 pubmed=display_regular_ligand(pdbid,asym_id,lig3,ligIdx,title)

   1444         else:

=> 1445             pubmed,uniprot=display_protein_receptor(pdbid,asym_id,title)

   1446     

   1447     uniprot_line=''

pubmed = '', uniprot = '', display_protein_receptor = <function display_protein_receptor>, pdbid = '7tbl', asym_id = 'A5', title = 'Architecture of the cytoplasmic face of the nuclear pore.'

 /var/www/html/BioLiP/pdb.cgi in display_protein_receptor(pdbid='7tbl', asym_id='A5', title='Architecture of the cytoplasmic face of the nuclear pore.')

    839 

    840     if go:

=>  841         display_go(go,uniprot,pdbid,asym_id)

    842     return pubmed,uniprot

    843 

global display_go = <function display_go>, go = '0005643,0006913,0017056', uniprot = '', pdbid = '7tbl', asym_id = 'A5'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0005643,0006913,0017056', uniprot='', pdbid='7tbl', asym_id='A5')

    480         '''.replace("$namespace_link",namespace_link

    481           ).replace("$namespace",namespace

=>  482           ).replace("$uniprot",u

    483         ))

    484         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>