Structure of PDB 7tbk Chain A5

Receptor sequence

>7tbkA5 (length=1276) Species: 9606 (Homo sapiens)

DLPPVAKAAQVVNQTLQLDDSYPDLDSYCRPGASSDYEMQSSDSSWAPFH
VVRHHNIPDKVFEHLNAGEVFTKLGLFAEIGYAWASIDSSLFLWDYTHPN
PELIGYEEATHTITAVALVPPKPGVFVKTITHVLVVATTSEIILLGVSAT
PTPSGSKSLTLYSTRMSVHRGGSDVSFIVGTKDGRIFLGGESDTDIHEIF
YQQEERWFSSRCGKINHSHPFGSRQQEWLRGLYVDDTRNLLYSLSNRSTI
RTYHMEGPEKLTKVIEKDKTSCLRDFAHMADSSPLFTDKTNIVALSPIPA
TEASKLHLMALTDTGCRLFLSATSSASYTALAPQSMQLQFVKFPPRESPT
RIRTLSQLDKTSRALDPSALGFRFSPGYFFDVVRKHPNQDMLFVSAPDTG
RIKVTQPASALKYFEQGTWIELENGNRTIEIGLTTAPFAAAKQPLGFGNE
LAVQFDQVPGEFAVLTNTGVHIVRRRRLVDIFAKALGNCVSASDDALERE
VRKFINQYGRVETIAAALAVACGQGSDLMDRNTENLARAAFIEYGGQPRL
ASVRLSSRHDALALYLTRLVRTLWKAKVVQVDISSTIPTSKLVTIQENVE
RLRNFLEANKSTIQGLAPPDIANQKEHQALHALQKLMESISEGISFVLML
FDERVSDIYARLDAVSQQQLKDLTYEQLFSQTPGKELAKVLVKAIVNRNI
ASGANVETVADALRRRCGSFCSPDDVVTFKAQEQLQRASEQAHNSPVLRA
LLAESLRLFEQVAGSLTPANLTTAVEQMISLKYYAGAIQLCLTVAQQKDR
GNTALSWVNDGKPANDSRKKAFDERKICYNLIHQVLDKLESDFAGEPELV
DGRPTLAATKRMEAYNVVNDSSDEVFHFDMYEWYIEKGWTDRILSIDSPH
VITYLQRLAETDFRHAELLCRFYTTRSRFFEAAQVQTNLAKSDLNISLKD
RIILLSRAKGNASVNTIGISRQQQQQLNHEASELLEIAHIQDDLLERLVA
DPRIPEERKAEIEEFLDGPIRTLTDLFNDYADQANYYDLCLLIFHAADFH
NPRTIMDTWNNLINQSHFEAEQRREYWEIVQAGGDLPAGVIAEPPLPYVY
VSQQIQLIAHRTSLDSLIFPVNSLLPVVCAYAINNGQDASIGADPCWPIQ
LFLNLGVPHALMVQVLENVLDTQEAPFTGRRRKLVVQWIAMAVDMWVREV
ERRGAMAAAVMGSWVSELLGRADQVLTQIAGTGATLRGGAASDAEEIASL
RRTVKGLKRSVDMLLGGEMARMSFFR

3D structure

• PDB: 7tbk Architecture of the linker-scaffold in the nuclear pore.
• Chain: A5
• Resolution: 37.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A5	G178 V198 F199 V200 I203 L234 Y235 S236 R238 Q276	G105 V125 F126 V127 I130 L161 Y162 S163 R165 Q203
BS02	peptide	A5	F144 K146 L147 F150 I153 Y155 A156 W157 A158 S159 I160 D161 S162 S163 L164 F165 L166 H171 P172 N173 E175 I177 G178 Y179 E180 I186 T187 A188 V189 A190 L191 V209 G219 V220 S221 A222 S231 L232 T233 L234 Y235 S249	F71 K73 L74 F77 I80 Y82 A83 W84 A85 S86 I87 D88 S89 S90 L91 F92 L93 H98 P99 N100 E102 I104 G105 Y106 E107 I113 T114 A115 V116 A117 L118 V136 G146 V147 S148 A149 S158 L159 T160 L161 Y162 S176
BS03	peptide	A5	R1135 L1150 T1151 F1154 N1155 D1159 Q1160 A1161	R1008 L1023 T1024 F1027 N1028 D1032 Q1033 A1034

Gene Ontology

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UnboundLocalError

Python 3.6.8: /usr/bin/python3 Tue Nov 26 01:54:15 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1443                 pubmed=display_regular_ligand(pdbid,asym_id,lig3,ligIdx,title)

   1444         else:

=> 1445             pubmed,uniprot=display_protein_receptor(pdbid,asym_id,title)

   1446     

   1447     uniprot_line=''

pubmed = '', uniprot = '', display_protein_receptor = <function display_protein_receptor>, pdbid = '7tbk', asym_id = 'A5', title = 'Architecture of the linker-scaffold in the nuclear pore.'

 /var/www/html/BioLiP/pdb.cgi in display_protein_receptor(pdbid='7tbk', asym_id='A5', title='Architecture of the linker-scaffold in the nuclear pore.')

    839 

    840     if go:

=>  841         display_go(go,uniprot,pdbid,asym_id)

    842     return pubmed,uniprot

    843 

global display_go = <function display_go>, go = '0005643,0006913,0017056', uniprot = '', pdbid = '7tbk', asym_id = 'A5'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0005643,0006913,0017056', uniprot='', pdbid='7tbk', asym_id='A5')

    480         '''.replace("$namespace_link",namespace_link

    481           ).replace("$namespace",namespace

=>  482           ).replace("$uniprot",u

    483         ))

    484         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>