Structure of PDB 7tbm Chain A4

Receptor sequence

>7tbmA4 (length=1269) Species: 9606 (Homo sapiens)

DLPPVAKAAQVVNQTLQLDDSYPDLDSYCRPGASSDYEMQSSDSSWAPFH
VVRHHNIPDKVFEHLNAGEVFTKLGLFAEIGYAWASIDSSLFLWDYTHPN
PELIGYEEATHTITAVALVPPKPGVFVKTITHVLVVATTSEIILLGVSAT
PTPSGSKSLTLYSTRMSVHRGGSDVSFIVGTKDGRIFLGGESDTDIHEIF
YQQEERWFSSRCGKINHSHPFGSRQQEWLRGLYVDDTRNLLYSLSNRSTI
RTYHMEGPEKLTKVIEKDKTSCLRDFAHMADSSPLFTDKTNIVALSPIPA
TEASKLHLMALTDTGCRLFLSATSSALAPQSMQLQFVKFPPRESPTRIRT
LNSQLDKTSRALDPSALGFRFSPGYFFDVVRKHPNQDMLFVSAPDTGRIK
VTQPASALKYFEQGTWIELENGNRTIEIGLTTAPFAAAKQPLGFGNELAV
QFDQVPGEFAVLTNTGVHIVRRRRLVDIFAKALGNCVSASDDALEREVRK
FINQYGRVETIAAALAVACGQGSMDRNTENLARAAFIEYGGQPRLAAESV
RLSSRHDALALYLTRLVRTLWKAKVVQVGSGSDISSTIPTLVTIQENVER
LRNFLEANKSTIQGLAPPEDIANQKEHQALHALQKLMESISEGISFVLML
FDERVSDIYARLDAVSQQQLKDLTYEQLFSQTPGKELAKVLVKAIVNRNI
AAPDDVVTFKAQEQLQRASEQAHNAPVLRALLAESLRLFEQVAGSLTPAN
LTTAVEQMISLKYYAGAIQLCLTVAQQKDRGNTALSWVNDGKPANDSRKK
AFDERKICYNLIHQVLDKLESDFAGEPELVDGRPTLAATKRMEAYNVVND
SSDEVFHFDMYEWYIEKGWTDRILSIDSPHVITYLQRLAETDFRHAELLC
RFYTTRSRFFEAAQVQTNLAKSDLNISLKDRIILLSRAKGNASVNTIGIS
RQQQQQLNHEASELLEIAHIQDDLLERLVADPRIPEERKAEIEEFLDGPI
RTLTDLFNDYADQANYYDLCLLIFHAADFHNPRTIMDTWNNLINQSHFEA
EQRREYWEIVQAGGDLPAGVIAPIAEPPLPYVYVSQQIQLIAHRTSLDSL
IFPVNSLLPVVCAYAINNGQDASIGADPCWPIQLFLNLGVPHALMVQVLE
NVLDTQEAPFTGRRRKLVVQWIAMAVDMWVREVERRGAMAAAAASGASGS
EAVMGSWVSELLGRADQVLTQIAGTGATLRGGAASDAEEIASLRRTVKGL
KRSVDMLLGGEMARMSFFR

3D structure

• PDB: 7tbm Architecture of the cytoplasmic face of the nuclear pore.
• Chain: A4
• Resolution: 37.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A4	G178 V198 F199 V200 I203 L234 Y235 R238 Q276	G105 V125 F126 V127 I130 L161 Y162 R165 Q203
BS02	peptide	A4	P895 L898 T899 V902 G913 A914 I915 Q916 L917 C918 W934 P940 N942 D943 S944 R945 K946 K947 A948 F949 D950 E951 R952 K953 I954 C955 L958 Q961	P748 L751 T752 V755 G766 A767 I768 Q769 L770 C771 W787 P793 N795 D796 S797 R798 K799 K800 A801 F802 D803 E804 R805 K806 I807 C808 L811 Q814
BS03	peptide	A4	E1110 I1114 R1148 T1149 L1150 T1151 F1154 N1155 Q1160	E963 I967 R1001 T1002 L1003 T1004 F1007 N1008 Q1013

Gene Ontology

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UnboundLocalError

Python 3.6.8: /usr/bin/python3 Fri Nov 22 23:12:04 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1443                 pubmed=display_regular_ligand(pdbid,asym_id,lig3,ligIdx,title)

   1444         else:

=> 1445             pubmed,uniprot=display_protein_receptor(pdbid,asym_id,title)

   1446     

   1447     uniprot_line=''

pubmed = '', uniprot = '', display_protein_receptor = <function display_protein_receptor>, pdbid = '7tbm', asym_id = 'A4', title = 'Architecture of the cytoplasmic face of the nuclear pore.'

 /var/www/html/BioLiP/pdb.cgi in display_protein_receptor(pdbid='7tbm', asym_id='A4', title='Architecture of the cytoplasmic face of the nuclear pore.')

    839 

    840     if go:

=>  841         display_go(go,uniprot,pdbid,asym_id)

    842     return pubmed,uniprot

    843 

global display_go = <function display_go>, go = '0005643,0006913,0017056', uniprot = '', pdbid = '7tbm', asym_id = 'A4'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0005643,0006913,0017056', uniprot='', pdbid='7tbm', asym_id='A4')

    480         '''.replace("$namespace_link",namespace_link

    481           ).replace("$namespace",namespace

=>  482           ).replace("$uniprot",u

    483         ))

    484         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>