Structure of PDB 7tbl Chain A2

Receptor sequence

>7tblA2 (length=1269) Species: 9606 (Homo sapiens)

DLPPVAKAAQVVNQTLQLDDSYPDLDSYCRPGASSDYEMQSSDSSWAPFH
VVRHHNIPDKVFEHLNAGEVFTKLGLFAEIGYAWASIDSSLFLWDYTHPN
PELIGYEEATHTITAVALVPPKPGVFVKTITHVLVVATTSEIILLGVSAT
PTPSGSKSLTLYSTRMSVHRGGSDVSFIVGTKDGRIFLGGESDTDIHEIF
YQQEERWFSSRCGKINHSHPFGSRQQEWLRGLYVDDTRNLLYSLSNRSTI
RTYHMEGPEKLTKVIEKDKTSCLRDFAHMADSSPLFTDKTNIVALSPIPA
TEASKLHLMALTDTGCRLFLSATSSALAPQSMQLQFVKFPPRESPTRIRT
LNSQLDKTSRALDPSALGFRFSPGYFFDVVRKHPNQDMLFVSAPDTGRIK
VTQPASALKYFEQGTWIELENGNRTIEIGLTTAPFAAAKQPLGFGNELAV
QFDQVPGEFAVLTNTGVHIVRRRRLVDIFAKALGNCVSASDDALEREVRK
FINQYGRVETIAAALAVACGQGSMDRNTENLARAAFIEYGGQPRLAAESV
RLSSRHDALALYLTRLVRTLWKAKVVQVGSGSDISSTIPTLVTIQENVER
LRNFLEANKSTIQGLAPPEDIANQKEHQALHALQKLMESISEGISFVLML
FDERVSDIYARLDAVSQQQLKDLTYEQLFSQTPGKELAKVLVKAIVNRNI
AAPDDVVTFKAQEQLQRASEQAHNAPVLRALLAESLRLFEQVAGSLTPAN
LTTAVEQMISLKYYAGAIQLCLTVAQQKDRGNTALSWVNDGKPANDSRKK
AFDERKICYNLIHQVLDKLESDFAGEPELVDGRPTLAATKRMEAYNVVND
SSDEVFHFDMYEWYIEKGWTDRILSIDSPHVITYLQRLAETDFRHAELLC
RFYTTRSRFFEAAQVQTNLAKSDLNISLKDRIILLSRAKGNASVNTIGIS
RQQQQQLNHEASELLEIAHIQDDLLERLVADPRIPEERKAEIEEFLDGPI
RTLTDLFNDYADQANYYDLCLLIFHAADFHNPRTIMDTWNNLINQSHFEA
EQRREYWEIVQAGGDLPAGVIAPIAEPPLPYVYVSQQIQLIAHRTSLDSL
IFPVNSLLPVVCAYAINNGQDASIGADPCWPIQLFLNLGVPHALMVQVLE
NVLDTQEAPFTGRRRKLVVQWIAMAVDMWVREVERRGAMAAAAASGASGS
EAVMGSWVSELLGRADQVLTQIAGTGATLRGGAASDAEEIASLRRTVKGL
KRSVDMLLGGEMARMSFFR

3D structure

• PDB: 7tbl Architecture of the cytoplasmic face of the nuclear pore.
• Chain: A2
• Resolution: 23.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A2	G178 V198 F199 V200 I203 L234 Y235 R238 Q276	G105 V125 F126 V127 I130 L161 Y162 R165 Q203
BS02	peptide	A2	A1158 Q1160 A1161 N1162 Y1163 Y1164 C1167 L1168 T1185	A1011 Q1013 A1014 N1015 Y1016 Y1017 C1020 L1021 T1038
BS03	peptide	A2	E1110 I1114 R1148 T1149 L1150 T1151 F1154 N1155 Q1160	E963 I967 R1001 T1002 L1003 T1004 F1007 N1008 Q1013

Gene Ontology

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UnboundLocalError

Python 3.6.8: /usr/bin/python3 Fri Nov 22 22:00:08 2024

A problem occurred in a Python script. Here is the sequence of function calls leading up to the error, in the order they occurred.

 /var/www/html/BioLiP/pdb.cgi in <module>()

   1443                 pubmed=display_regular_ligand(pdbid,asym_id,lig3,ligIdx,title)

   1444         else:

=> 1445             pubmed,uniprot=display_protein_receptor(pdbid,asym_id,title)

   1446     

   1447     uniprot_line=''

pubmed = '', uniprot = '', display_protein_receptor = <function display_protein_receptor>, pdbid = '7tbl', asym_id = 'A2', title = 'Architecture of the cytoplasmic face of the nuclear pore.'

 /var/www/html/BioLiP/pdb.cgi in display_protein_receptor(pdbid='7tbl', asym_id='A2', title='Architecture of the cytoplasmic face of the nuclear pore.')

    839 

    840     if go:

=>  841         display_go(go,uniprot,pdbid,asym_id)

    842     return pubmed,uniprot

    843 

global display_go = <function display_go>, go = '0005643,0006913,0017056', uniprot = '', pdbid = '7tbl', asym_id = 'A2'

 /var/www/html/BioLiP/pdb.cgi in display_go(go='0005643,0006913,0017056', uniprot='', pdbid='7tbl', asym_id='A2')

    480         '''.replace("$namespace_link",namespace_link

    481           ).replace("$namespace",namespace

=>  482           ).replace("$uniprot",u

    483         ))

    484         for l,(term,name) in enumerate(go2aspect[Aspect]):

u undefined

UnboundLocalError: local variable 'u' referenced before assignment
      args = ("local variable 'u' referenced before assignment",)
      with_traceback = <built-in method with_traceback of UnboundLocalError object>