Structure of PDB 8bhf Chain A1

Receptor sequence

>8bhfA1 (length=203) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]

GAYKYIQELWRKKQSDVMRFLLRVRCWQYRQLSALHRAPRPTRPDKARRL
GYKAKQGYVIYRIRVRRGGRKRPVPKGATYGKPVHHGVNQLKFARSLQSV
AEERAGRHCGALRVLNSYWVGEDSTYKFFEVILIDPFHKAIRRNPDTQWI
TKPVHKHREMRGLTSAGRKSRGLGKGHKFHHTIGGSRRAAWRRRNTLQLH
RYR

3D structure

PDB

8bhf Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2.

Chain

Resolution

3.1 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A1	G2 Y4 K5 Q8 R12 K14 Q15 R24 W28 R31 S34 P40 R41 R44 K47 R49 R50 L51 K54 A55 K56 R65 R67 R68 G69 G70 R71 K72 R73 P74 P76 K77 Y81 G82 K83 P84 V85 H86 H87 V89 N90 Q91 K93 F94 A95 R96 S97 E104 R105 R108 A112 N117 W120 S125 Y127 K128 F138 K140 R144 W150 P154 V155 K157 H158 M161 R162 L164 S166 R169 K170 S171 R172 L174 K176 G177 H178 K179 F180 H181 H182 G185 G186 S187 R189 W192 R193 R194 R195 Q199 H201 R202 Y203 R204	G1 Y3 K4 Q7 R11 K13 Q14 R23 W27 R30 S33 P39 R40 R43 K46 R48 R49 L50 K53 A54 K55 R64 R66 R67 G68 G69 R70 K71 R72 P73 P75 K76 Y80 G81 K82 P83 V84 H85 H86 V88 N89 Q90 K92 F93 A94 R95 S96 E103 R104 R107 A111 N116 W119 S124 Y126 K127 F137 K139 R143 W149 P153 V154 K156 H157 M160 R161 L163 S165 R168 K169 S170 R171 L173 K175 G176 H177 K178 F179 H180 H181 G184 G185 S186 R188 W191 R192 R193 R194 Q198 H200 R201 Y202 R203
BS02	rna	A1	R38 Q57 V60 Y62 H109 C110 D136 H139	R37 Q56 V59 Y61 H108 C109 D135 H138

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0044391	ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8bhf, PDBe:8bhf, PDBj:8bhf
PDBsum	8bhf
PubMed	37653241
UniProt	G1T0C1\|RL15_RABIT Large ribosomal subunit protein eL15 (Gene Name=RPL15)

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