Structure of PDB 8apk Chain A1

Receptor sequence

>8apkA1 (length=524) Species: 5702 (Trypanosoma brucei brucei)

FFKTTEMIGYVHSIDGTIATLIPAPGNPGVAYNTIIQIQVSPTTFAAGLV
FNLEKDGRIGIILMDNITEVQSGQKVMATGQLLHIPVGAGVLGKVVNPLG
HEVPVGLSTLGKVDTGAPNIVSRSPVNYNLLTGFKAVDTMIPIGRGQREL
IVGDRQTGKTSIAVSTIINQVRINQQILSKNAVISIYVSIGQRCSNVARI
HRLLQSYGALRYTTVMAATAAEPAGLQYLAPYAGVTMGEYFMNRGRHCLC
VYDDLSKQAVAYRQISLLLRRPPGREAYPGDVFYLHSRLLERAAMLSPGK
GGGSVTALPIVETLSNDVTAYIVTNVISITDGQIYLDTKLFTGGQRPAVN
IGLSVSRVGSSAQNAAMKGVAGKLKGILAEYRKLAQVQTIPMIRGARFVA
LFNQKQPSYFMNAIVSLYACLNGYLDDVKVQYVKFYEYLLVHRDLGIMYG
TAKNKFFYMYVQELNYLIRFFTLNSPILHGELEEMLKQHTHLFLQHYQSK
MNAIKSEKDVKALKNLLYSCKRAV

3D structure

• PDB: 8apk An ancestral interaction module promotes oligomerization in divergent mitochondrial ATP synthases.
• Chain: A1
• Resolution: 3.7 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ATP	A1	Q209 T210 G211 K212 T213 S214 R399 P400 Q464 K465	Q156 T157 G158 K159 T160 S161 R346 P347 Q404 K405
BS02	MG	A1	T213 D306	T160 D253
BS03	ATP	A1	V408 R410	V355 R357

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0032559 adenyl ribonucleotide binding
• GO:0043531 ADP binding
• GO:0046933 proton-transporting ATP synthase activity, rotational mechanism

Biological Process

• GO:0006754 ATP biosynthetic process
• GO:0015986 proton motive force-driven ATP synthesis
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)

External links

• PDB: RCSB:8apk, PDBe:8apk, PDBj:8apk
• PDBsum: 8apk
• PubMed: 36220811
• UniProt: Q9GS23|ATPA_TRYBB ATP synthase subunit alpha, mitochondrial (Gene Name=Tb427.07.7420)