Structure of PDB 9ium Chain A

Receptor sequence
>9iumA (length=1334) Species: 237561 (Candida albicans SC5314) [Search protein sequence]
EYHGFDAHTSENIQNLARTFTHDSFNDQLNPDSENFNAKFWVKNLRKLFE
SDPEYYKPSKLGIGYRNLRAYGVPTVTNALWKLATEGFRHFQRYFDILKS
MDAIMRPGELTVVLGRPGAGCSTLLKTIAVNTYGFHIGKESQITYDGLSP
HDIERHYRGDVIYSAETDVHFPHLSVGDTLEFAARLRTPQNRGEGIDRET
YAKHMASVYMATYGLSHTRNTNVGNDFVRGVSGGERKRVSIAEASLSGAN
IQCWDNATRGLDSATALEFIRALKTSAVILDTTPLIAIYQCSQDAYDLFD
KVVVLYEGYQIFFGKATKAKEYFEKMGWKCPQRQTTADFLTSLTNPAERE
PLPGYEDKVPRTAQEFETYWKNSPEYAELTKEIDEYFVECERSPASPYTV
SFFMQVRYGVARNFLRMKGDPSIPIFSVFGQLVMGLILSSVFYNLSQTTG
SFYYRGAAMFFAVLFNAFSSLLEIMSLFEARPIVEKHKKYALYRPSADAL
ASIISELPVKLAMSMSFNFVFYFMVNFRRNPGRFFFYWLMCIWCTFVMSH
LFRSIGAVSTSISGAMTPATVLLLAMVIYTGFVIPTPSMLGWSRWINYIN
PVGYVFESLMVNEFHGREFQCAQYVPSGPGYENISRSNQVCTAVGSVPGN
EMVSGTNYLAGAYQYYNSHKWRNLGITIGFAVFFLAIYIALTEFNKGNRE
IFFWRDLTYQVKIKKEDRVILDHVDGWVKPGQITALMGASGAGKTTLLNC
LSERVTTGIITDGERLVNGHALDSSFQRSIGYVQQQDVHLETTTVREALQ
FSAYLRQSNKISKKEKDDYVDYVIDLLEMTDYADALVGVAGEGLNVEQRK
RLTIGVELVAKPKLLLFLDEPTSGLDSQTAWSICKLMRKLADHGQAILCT
IHQPSALIMAEFDRLLFLQKGGRTAYFGELGENCQTMINYFEKYGADPCP
KEANPAEWMLQVVGAAPGSHAKQDYFEVWRNSSEYQAVREEINRMEAELS
KLPRDNDPEALLKYAAPLWKQYLLVSWRTIVQDWRSPGYIYSKIFLVVSA
ALFNGFSFFKAKNNMQGLQNQMFSVFMFFIPFNTLVQQMLPYFVKQRDVY
EVREAPSRTFSWFAFIAGQITSEIPYQVAVGTIAFFCWYYPLGLYNNATP
TDSVNPRGVLMWMLVTAFYVYTATMGQLCMSFSELADNAANLATLLFTMC
LNFCGVLAGPDVLPGFWIFMYRCNPFTYLVQAMLSTGLANTFVKCAEREY
VSVKPPNGESCSTYLDPYIKFAGGYFETRNDGSCAFCQMSSTNTFLKSVN
SLYSERWRNFGIFIAFIAINIILTVIFYWLARVP
3D structure
PDB9ium Cryo-EM structures of Candida albicans Cdr1 reveal azole-substrate recognition and inhibitor blocking mechanisms.
ChainA
Resolution3.08 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1L26 A G623 R624 F626 I633 F637 H706 N758 W762 G532 R533 F535 I542 F546 H615 N667 W671
BS02 A1L27 A F556 F559 L562 M657 T661 L664 I1237 N1240 T1351 T1355 F465 F468 L471 M566 T570 L573 I1080 N1083 T1194 T1198
External links
PDB RCSB:9ium, PDBe:9ium, PDBj:9ium
PDBsum9ium
PubMed39242571
UniProtQ5ANA3|CDR1_CANAL Pleiotropic ABC efflux transporter of multiple drugs CDR1 (Gene Name=CDR1)

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