Structure of PDB 9iul Chain A

Receptor sequence
>9iulA (length=1335) Species: 237561 (Candida albicans SC5314) [Search protein sequence]
EYHGFDAHTSENIQNLARTFTHDSFKNDQLNPDSENFNAKFWVKNLRKLF
ESDPEYYKPSKLGIGYRNLRAYGVPTVTNALWKLATEGFRHFQRYFDILK
SMDAIMRPGELTVVLGRPGAGCSTLLKTIAVNTYGFHIGKESQITYDGLS
PHDIERHYRGDVIYSAETDVHFPHLSVGDTLEFAARLRTPQNRGEGIDRE
TYAKHMASVYMATYGLSHTRNTNVGNDFVRGVSGGERKRVSIAEASLSGA
NIQCWDNATRGLDSATALEFIRALKTSAVILDTTPLIAIYQCSQDAYDLF
DKVVVLYEGYQIFFGKATKAKEYFEKMGWKCPQRQTTADFLTSLTNPAER
EPLPGYEDKVPRTAQEFETYWKNSPEYAELTKEIDEYFVECERSPASPYT
VSFFMQVRYGVARNFLRMKGDPSIPIFSVFGQLVMGLILSSVFYNLSQTT
GSFYYRGAAMFFAVLFNAFSSLLEIMSLFEARPIVEKHKKYALYRPSADA
LASIISELPVKLAMSMSFNFVFYFMVNFRRNPGRFFFYWLMCIWCTFVMS
HLFRSIGAVSTSISGAMTPATVLLLAMVIYTGFVIPTPSMLGWSRWINYI
NPVGYVFESLMVNEFHGREFQCAQYVPSGPGYENISRSNQVCTAVGSVPG
NEMVSGTNYLAGAYQYYNSHKWRNLGITIGFAVFFLAIYIALTEFNKGNR
EIFFWRDLTYQVKIKKEDRVILDHVDGWVKPGQITALMGASGAGKTTLLN
CLSERVTTGIITDGERLVNGHALDSSFQRSIGYVQQQDVHLETTTVREAL
QFSAYLRQSNKISKKEKDDYVDYVIDLLEMTDYADALVGVAGEGLNVEQR
KRLTIGVELVAKPKLLLFLDEPTSGLDSQTAWSICKLMRKLADHGQAILC
TIHQPSALIMAEFDRLLFLQKGGRTAYFGELGENCQTMINYFEKYGADPC
PKEANPAEWMLQVVGAAPGSHAKQDYFEVWRNSSEYQAVREEINRMEAEL
SKLPRDNDPEALLKYAAPLWKQYLLVSWRTIVQDWRSPGYIYSKIFLVVS
AALFNGFSFFKAKNNMQGLQNQMFSVFMFFIPFNTLVQQMLPYFVKQRDV
YEVREAPSRTFSWFAFIAGQITSEIPYQVAVGTIAFFCWYYPLGLYNNAT
PTDSVNPRGVLMWMLVTAFYVYTATMGQLCMSFSELADNAANLATLLFTM
CLNFCGVLAGPDVLPGFWIFMYRCNPFTYLVQAMLSTGLANTFVKCAERE
YVSVKPPNGESCSTYLDPYIKFAGGYFETRNDGSCAFCQMSSTNTFLKSV
NSLYSERWRNFGIFIAFIAINIILTVIFYWLARVP
3D structure
PDB9iul Cryo-EM structures of Candida albicans Cdr1 reveal azole-substrate recognition and inhibitor blocking mechanisms.
ChainA
Resolution3.3 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1L26 A G623 R624 I633 F637 N758 K761 W762 G533 R534 I543 F547 N668 K671 W672
BS02 TPF A F552 F556 F559 N1240 F1354 T1355 N1359 F462 F466 F469 N1084 F1198 T1199 N1203
External links
PDB RCSB:9iul, PDBe:9iul, PDBj:9iul
PDBsum9iul
PubMed39242571
UniProtQ5ANA3|CDR1_CANAL Pleiotropic ABC efflux transporter of multiple drugs CDR1 (Gene Name=CDR1)

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