Structure of PDB 9iuk Chain A

Receptor sequence

>9iukA (length=1335) Species: 237561 (Candida albicans SC5314) [Search protein sequence]

EYHGFDAHTSENIQNLARTFTHDSFKNDQLNPDSENFNAKFWVKNLRKLF
ESDPEYYKPSKLGIGYRNLRAYGVPTVTNALWKLATEGFRHFQRYFDILK
SMDAIMRPGELTVVLGRPGAGCSTLLKTIAVNTYGFHIGKESQITYDGLS
PHDIERHYRGDVIYSAETDVHFPHLSVGDTLEFAARLRTPQNRGEGIDRE
TYAKHMASVYMATYGLSHTRNTNVGNDFVRGVSGGERKRVSIAEASLSGA
NIQCWDNATRGLDSATALEFIRALKTSAVILDTTPLIAIYQCSQDAYDLF
DKVVVLYEGYQIFFGKATKAKEYFEKMGWKCPQRQTTADFLTSLTNPAER
EPLPGYEDKVPRTAQEFETYWKNSPEYAELTKEIDEYFVECERSPASPYT
VSFFMQVRYGVARNFLRMKGDPSIPIFSVFGQLVMGLILSSVFYNLSQTT
GSFYYRGAAMFFAVLFNAFSSLLEIMSLFEARPIVEKHKKYALYRPSADA
LASIISELPVKLAMSMSFNFVFYFMVNFRRNPGRFFFYWLMCIWCTFVMS
HLFRSIGAVSTSISGAMTPATVLLLAMVIYTGFVIPTPSMLGWSRWINYI
NPVGYVFESLMVNEFHGREFQCAQYVPSGPGYENISRSNQVCTAVGSVPG
NEMVSGTNYLAGAYQYYNSHKWRNLGITIGFAVFFLAIYIALTEFNKGNR
EIFFWRDLTYQVKIKKEDRVILDHVDGWVKPGQITALMGASGAGKTTLLN
CLSERVTTGIITDGERLVNGHALDSSFQRSIGYVQQQDVHLETTTVREAL
QFSAYLRQSNKISKKEKDDYVDYVIDLLEMTDYADALVGVAGEGLNVEQR
KRLTIGVELVAKPKLLLFLDEPTSGLDSQTAWSICKLMRKLADHGQAILC
TIHQPSALIMAEFDRLLFLQKGGRTAYFGELGENCQTMINYFEKYGADPC
PKEANPAEWMLQVVGAAPGSHAKQDYFEVWRNSSEYQAVREEINRMEAEL
SKLPRDNDPEALLKYAAPLWKQYLLVSWRTIVQDWRSPGYIYSKIFLVVS
AALFNGFSFFKAKNNMQGLQNQMFSVFMFFIPFNTLVQQMLPYFVKQRDV
YEVREAPSRTFSWFAFIAGQITSEIPYQVAVGTIAFFCWYYPLGLYNNAT
PTDSVNPRGVLMWMLVTAFYVYTATMGQLCMSFSELADNAANLATLLFTM
CLNFCGVLAGPDVLPGFWIFMYRCNPFTYLVQAMLSTGLANTFVKCAERE
YVSVKPPNGESCSTYLDPYIKFAGGYFETRNDGSCAFCQMSSTNTFLKSV
NSLYSERWRNFGIFIAFIAINIILTVIFYWLARVP

3D structure

PDB

9iuk Cryo-EM structures of Candida albicans Cdr1 reveal azole-substrate recognition and inhibitor blocking mechanisms.

Chain

Resolution

3.38 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	A1L26	A	G623 R624 F626 W629 I633 F637 H706 K761	G533 R534 F536 W539 I543 F547 H616 K671

External links

PDB	RCSB:9iuk, PDBe:9iuk, PDBj:9iuk
PDBsum	9iuk
PubMed	39242571
UniProt	Q5ANA3\|CDR1_CANAL Pleiotropic ABC efflux transporter of multiple drugs CDR1 (Gene Name=CDR1)

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