Structure of PDB 9ik1 Chain A

Receptor sequence
>9ik1A (length=341) Species: 9606 (Homo sapiens) [Search protein sequence]
TYETPKVIVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIES
SVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCP
ESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVD
TVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPD
KDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIP
KYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVL
VYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKG
3D structure
PDB9ik1 Discovery of Triazolopyrimidine Derivatives as Selective P2X3 Receptor Antagonists Binding to an Unprecedented Allosteric Site as Evidenced by Cryo-Electron Microscopy.
ChainA
Resolution2.61 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1L2M A Y37 S331 V334 Y29 S323 V326
BS02 ATP A K63 K65 T172 F174 K55 K57 T164 F166
External links
PDB RCSB:9ik1, PDBe:9ik1, PDBj:9ik1
PDBsum9ik1
PubMed39102524
UniProtP56373|P2RX3_HUMAN P2X purinoceptor 3 (Gene Name=P2RX3)

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