Structure of PDB 9gbe Chain A

Receptor sequence
>9gbeA (length=304) Species: 9606 (Homo sapiens) [Search protein sequence]
STIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQV
SSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLP
RFILMELMAGRDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLE
ENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRAGCAMLPVKWMP
PEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGR
MDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTAL
PIEY
3D structure
PDB9gbe NVL-655 Is a Selective and Brain-Penetrant Inhibitor of Diverse ALK Mutant Oncoproteins, Including Lorlatinib-Resistant Compound Mutations
ChainA
Resolution1.58 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1IJ8 A L1122 A1148 M1199 R1202 N1254 L1256 G1269 D1270 L37 A57 M108 R111 N163 L165 G178 D179
External links
PDB RCSB:9gbe, PDBe:9gbe, PDBj:9gbe
PDBsum9gbe
PubMed
UniProtQ9UM73|ALK_HUMAN ALK tyrosine kinase receptor (Gene Name=ALK)

[Back to BioLiP]