Structure of PDB 9g7h Chain A

Receptor sequence

>9g7hA (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]

PFTADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTAS
GIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRF
LVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGL
KATGRLCTVACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTS
LQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLM
KHLGLEIPAWDGPRVLERALPPLPRPPTPKLE

3D structure

PDB

9g7h Elucidating the Unconventional Binding Mode of a DNA-Encoded Library Hit Provides a Blueprint for Sirtuin 6 Inhibitor Development.

Chain

Resolution

1.75 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	AR6	A	A53 G54 T57 D63 F64 R65 Q113 H133 G214 T215 S216 I219 N240 L241 Q242 G256 Y257 V258	A44 G45 T48 D54 F55 R56 Q104 H124 G198 T199 S200 I203 N224 L225 Q226 G240 Y241 V242
BS02	ZN	A	C141 C144 C166 C177	C132 C135 C157 C161
BS03	A1IIZ	A	P62 F64 F82 F86 V115 H133 M157 I185 L186 W188	P53 F55 F73 F77 V106 H124 M148 I169 L170 W172

External links

PDB	RCSB:9g7h, PDBe:9g7h, PDBj:9g7h
PDBsum	9g7h
PubMed	38940296
UniProt	Q8N6T7\|SIR6_HUMAN NAD-dependent protein deacylase sirtuin-6 (Gene Name=SIRT6)

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