Structure of PDB 9fqi Chain A

Receptor sequence
>9fqiA (length=384) Species: 9606 (Homo sapiens) [Search protein sequence]
KQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLR
LILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQ
SQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFF
GDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIF
TRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFR
LSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRS
YNPDLTGLCEKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMC
TSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFD
3D structure
PDB9fqi Accelerated Discovery of a Carbamate Scaffold Cbl-b Inhibitor using Generative Models and Structure-Based Drug Design
ChainA
Resolution1.954 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1IEV A P72 R141 T144 K145 L148 S218 T219 Y260 A262 F263 E268 Y363 M366 P36 R105 T108 K109 L112 S182 T183 Y224 A226 F227 E232 Y320 M323
BS02 ZN A C373 C376 C393 C396 C330 C333 C350 C353
BS03 ZN A C388 H390 C408 C411 C345 H347 C365 C368
External links
PDB RCSB:9fqi, PDBe:9fqi, PDBj:9fqi
PDBsum9fqi
PubMed39132828
UniProtQ13191|CBLB_HUMAN E3 ubiquitin-protein ligase CBL-B (Gene Name=CBLB)

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