Structure of PDB 9fhe Chain A

Receptor sequence
>9fheA (length=296) Species: 9606 (Homo sapiens) [Search protein sequence]
GSQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCTVLSL
LGAPCAFMGSMAPGHVADFLVADFRRRGVDVSQVAWQSKGDTPSSCCIIN
NSNGNRTIVLHDTSLPDVSATDFEKVDLTQFKWIHIEGRNASEQVKMLQR
IDAHNTRQPPEQKIRVSVEVEKPREELFQLFGYGDVVFVSKDVAKHLGFQ
SAEEALRGLYGRVRKGAVLVCAWAEEGADALGPDGKLLHSDAFPPPRVVD
TLGAGDTFNASVIFSLSQGRSVQEALRFGCQVAGKKCGLQGFDGIV
3D structure
PDB9fhe Discovery of BI-9787, a potent zwitterionic ketohexokinase inhibitor with oral bioavailability.
ChainA
Resolution2.313 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1ICK A R108 A224 A226 E227 P246 V250 T253 A256 G257 C289 R106 A222 A224 E225 P244 V248 T251 A254 G255 C287
External links
PDB RCSB:9fhe, PDBe:9fhe, PDBj:9fhe
PDBsum9fhe
PubMed39179180
UniProtP50053|KHK_HUMAN Ketohexokinase (Gene Name=KHK)

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