Structure of PDB 9fet Chain A

Receptor sequence

>9fetA (length=313) Species: 9606 (Homo sapiens) [Search protein sequence]

FPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEY
GPLFSELKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYR
FMVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDI
KAANLLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFT
SLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNL
LDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKILNPHG
IPLGPLDFSTKGQ

3D structure

PDB

9fet Crystal Structure of Human Vaccinia-related kinase 2 (VRK-2) bound to JA-47

Chain

Resolution

2.4 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	REB	A	I43 V59 K61 M121 E122 R123 L124 L173	I29 V45 K47 M104 E105 R106 L107 L156

External links

PDB	RCSB:9fet, PDBe:9fet, PDBj:9fet
PDBsum	9fet
PubMed
UniProt	Q86Y07\|VRK2_HUMAN Serine/threonine-protein kinase VRK2 (Gene Name=VRK2)

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