Structure of PDB 9feh Chain A

Receptor sequence
>9fehA (length=264) Species: 9606,2697049 [Search protein sequence]
RLPAHLRLQPIYWSRDDVAQWLKWAENEFSLRPIDSNTFEMNGKALLLLT
KEDFRYRSPHSGDELYELLQHILKQPAAGDELKINAACRKVQHMVVKAAL
LADKFPVLHDIGNPKAIKCVPQADVEWKFYDAQPCSDKAYKIEELFYSYA
THSDKFTDGVCLFWNCNVDRYPANSIVCRFKSAFVNLKQLPFFYYSDSPC
ESHDYVPLKSATCITRCNLGGAVCRHHANEYRLYLDAYNMMISAGFSLWV
YKQFDTYNLWNTFT
3D structure
PDB9feh Structure of SARS-CoV-2 MTase nsp14 with the inhibitor STM957 reveals inhibition mechanism that is shared with a poxviral MTase VP39.
ChainA
Resolution1.99 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1IB6 A G333 P335 D352 A353 L366 F367 Y368 C387 N388 F506 G112 P114 D131 A132 L145 F146 Y147 C166 N167 F246
BS02 ZN A C452 C477 C484 H487 C200 C217 C224 H227
External links
PDB RCSB:9feh, PDBe:9feh, PDBj:9feh
PDBsum9feh
PubMed39188530
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep);
P41212|ETV6_HUMAN Transcription factor ETV6 (Gene Name=ETV6)

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