Structure of PDB 9fb8 Chain A

Receptor sequence
>9fb8A (length=417) Species: 9606 (Homo sapiens) [Search protein sequence]
RMQLSEEQAAVLRAVLKGQSIFFTGSAGTGKSYLLKRILGSLPPTGTVAT
ASTGVAACHIGGTTLHAFAGIGSGQAPLAQCVALAQRPGVRQGWLNCQRL
VIDEISMVEADLFDKLEAVARAVRQQNKPFGGIQLIICGDFLQLPPVTKG
SQPPRFCFQSKSWKRCVPVTLELTKVWRQADQTFISLLQAVRLGRCSDEV
TRQLQATASHKVGRDGIVATRLCTHQDDVALTNERRLQELPGKVHRFEAM
DSNPELASTLDAQCPVSQLLQLKLGAQVMLVKNLSVSRGLVNGARGVVVG
FEAEGRGLPQVRFLCGVTEVIHADRWTVQATGGQLLSRQQLPLQLAWAMS
IHKSQGMTLDCVEISLGRVFASGQAYVALSRARSLQGLRVLDFDPMAVRC
DPRVLHFYATLRRGRSL
3D structure
PDB9fb8 Structure-based discovery of first on-target inhibitors of the human PIF1 helicase
ChainA
Resolution1.727 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A M205 Q211 G231 G233 K234 S235 Y236 W380 R381 R584 L620 M2 Q8 G28 G30 K31 S32 Y33 W177 R178 R381 L417
BS02 O0J A V258 Q466 C467 P468 M482 Q547 L548 M552 K556 V55 Q263 C264 P265 M279 Q344 L345 M349 K353
BS03 O0J A F361 Q362 R606 F610 F158 Q159 R403 F407
External links
PDB RCSB:9fb8, PDBe:9fb8, PDBj:9fb8
PDBsum9fb8
PubMed
UniProtQ9H611|PIF1_HUMAN ATP-dependent DNA helicase PIF1 (Gene Name=PIF1)

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