Structure of PDB 9fa6 Chain A

Receptor sequence

>9fa6A (length=501) Species: 9606 (Homo sapiens) [Search protein sequence]

ARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRME
LSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPA
QNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLP
EEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQ
PGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLG
FTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPE
AAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQ
SVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDS
PIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALM
HPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWRRQHHH
H

3D structure

PDB

9fa6 Fragment-Based Discovery of a Series of Allosteric-Binding Site Modulators of beta-Glucocerebrosidase.

Chain

Resolution

1.49 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	A1IBE	A	D166 W218 E274 F285 Y352 E379 S384 W420 N435 V437	D127 W179 E235 F246 Y313 E340 S345 W381 N396 V398
BS02	A1IBG	A	H404 T408 L411 N481 L483 D484	H365 T369 L372 N442 L444 D445
BS03	A1IBE	A	P68 T69 F70 Y79 E150 R209 K464 F465 P467 H490	P29 T30 F31 Y40 E111 R170 K425 F426 P428 H451

External links

PDB	RCSB:9fa6, PDBe:9fa6, PDBj:9fa6
PDBsum	9fa6
PubMed	38932616
UniProt	P04062\|GBA1_HUMAN Lysosomal acid glucosylceramidase (Gene Name=GBA1)

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