Structure of PDB 9f7w Chain A

Receptor sequence
>9f7wA (length=271) Species: 9606 (Homo sapiens) [Search protein sequence]
GPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNS
LMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIP
GFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLK
SLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVK
PIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQ
VIKKTETDMSLHPLLQEIYKD
3D structure
PDB9f7w Structural Studies on the Binding Mode of Bisphenols to PPAR gamma.
ChainA
Resolution1.25 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K301 L311 N312 Q314 P467 L468 E471 K97 L107 N108 Q110 P263 L264 E267
BS02 2OH A I262 K263 R280 G284 C285 I58 K59 R76 G80 C81
BS03 2OH A F287 S464 L465 H466 F83 S260 L261 H262
External links
PDB RCSB:9f7w, PDBe:9f7w, PDBj:9f7w
PDBsum9f7w
PubMed38927044
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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