Structure of PDB 9f6c Chain A

Receptor sequence
>9f6cA (length=717) Species: 9913 (Bos taurus) [Search protein sequence]
LKKDVFVPDDKEEFVKATILSREGGKVTAETEHGKTVTVKEDQVLQQNPP
KFDKIEDMAMLTFLHEPAVLYNLKERYASWMIYTYSGLFCVTINPYKWLP
VYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILITGESGA
GKTVNTKRVIQYFAVIAAITGKGTLEDQIIQANPALEAFGNAKTVRNDNS
SRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILS
NKKPELLDMLLITNNPYDYAFISQGETTVASIDDAEELMATDNAFDVLGF
TTEEKNSMYKLTGAIMHFGNMKFKLKQREQAEPDGTEEADKSAYLMGLNS
ADLLKGLCHPRVKVGNEYVTKGQNVQQVVYAKGALAKAVYERMFNWMVTR
INATLETKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHH
MFVLEQEEYKKEGIEWEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPK
ATDMTFKAKLFDNHLGKSSNFQKPRNIKGKPEAHFSLIHYAGTVDYNIIG
WLQKNKDPLNETVVDLYKKSSLKMLSSLFANYAQTVSALHRENLNKLMTN
LRSTHPHFVRCIIPNETKSPGVIDNPLVMHQLRCNGVLEGIRICRKGFPN
RILYGDFRQRYRILNPAAIPIDSRKGAEKLLGSLDIDHNQYKFGHTKVFF
KAGLLGLLEEMRDERLS
3D structure
PDB9f6c Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy.
ChainA
Resolution2.33 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A T185 S242 T153 S201
BS02 6I6 A R243 F244 G245 Y266 L267 I462 A463 F473 E474 I478 T481 N654 L655 R202 F203 G204 Y225 L226 I420 A421 F431 E432 I436 T439 N593 L594
BS03 ADP A N126 P127 G181 G183 K184 T185 V186 N238 N94 P95 G149 G151 K152 T153 V154 N197
External links
PDB RCSB:9f6c, PDBe:9f6c, PDBj:9f6c
PDBsum9f6c
PubMed39196032
UniProtQ9BE39|MYH7_BOVIN Myosin-7 (Gene Name=MYH7)

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