Structure of PDB 9f2r Chain A

Receptor sequence

>9f2rA (length=708) Species: 11320 (Influenza A virus) [Search protein sequence]

SMENFVRTNFNPMILERAEKTMKEYGENPQNEGNKFAAISTHMEVCFMYS
DFHFIDLEGNTIVKENDDAMLKHRFEIIEGQERNIAWTIVNSICNMTENS
KPRFLPDLYDYKTNKFIEIGVTRRKVEDYYYEKASKLKGENVYIHIFSFD
GEEMATDDEYILDEESRARIKTRLFVLRQELATAGLWDSFRQSELEEEFS
YPPTFQRLANQSLPPSFKDYHQFKAYVSSFKANGNIEAKLGAMSEKVNAQ
IESFDPRTIRELELPEGKFCTQRSKFLLMDAMKLSVLNPAHEGEGIPMKD
AKACLDTFWGWKKATIIKKHEKGVNTNYLMIWEQLLESIKEMEGKFLNLK
KTNHLKWGLGEGQAPEKMDFEDCKEVPDLFQYKSEPPEKRKLASWIQSEF
NKASELTNSNWIEFDELGNDVAPIEHIASRRRNFFTAEVSQCRASEYIMK
AVYINTALLNSSCTAMEEYQVIPIITKCRDTSGQRRTNLYGFIIKGRSHL
RNDTDVVNFISLEFSLTDPRNEIHKWEKYCVLEIGDMEIRTSISTIMKPV
YLYVRTNGTSKIKMKWGMEMRRCLLQSLQQVESMIEAESAVKEKDMTEPF
FRNRENDWPIGESPQGIEKGTIGKVCRVLLAKSVFNSIYASAQLEGFSAE
SRKLLLLIQAFRDNLDPGTFDLKGLYEAIEECIINDPWVLLNASWFNSFL
KAVQLSMG

3D structure

PDB

9f2r High-resolution structure of a replication-initiation like configuration of influenza polymerase active site visualises the essential role of a conserved dibasic motif in the PA subunit

Chain

Resolution

1.959 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	M472 H505 L506 R507 K567	M466 H499 L500 R501 K561
BS02	rna	A	K281 H326 K328 W363 G366 G368 Q369 A370 P371 K373 Y388 K389 S390 P392 P393 R503 H505 V512 N514 K534 R561 T562 N563 G564 K569	K275 H320 K322 W357 G360 G362 Q363 A364 P365 K367 Y382 K383 S384 P386 P387 R497 H499 V506 N508 K528 R555 T556 N557 G558 K563

External links

PDB	RCSB:9f2r, PDBe:9f2r, PDBj:9f2r
PDBsum	9f2r
PubMed
UniProt	H6QM92

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