Structure of PDB 9exx Chain A

Receptor sequence
>9exxA (length=148) Species: 9606 (Homo sapiens) [Search protein sequence]
LLKYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQF
FGDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISG
KLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNPQVAKEAG
3D structure
PDB9exx Identification of Novel Potent NSD2-PWWP1 Ligands Using Structure-Based Design and Computational Approaches.
ChainA
Resolution1.943 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.357: [histone H3]-lysine(36) N-dimethyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1H7Y A V230 Y233 W236 F266 F267 G268 A270 E272 Q321 V14 Y17 W20 F50 F51 G52 A54 E56 Q105
External links
PDB RCSB:9exx, PDBe:9exx, PDBj:9exx
PDBsum9exx
PubMed38748070
UniProtO96028|NSD2_HUMAN Histone-lysine N-methyltransferase NSD2 (Gene Name=NSD2)

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