Structure of PDB 9eu8 Chain A

Receptor sequence
>9eu8A (length=128) Species: 9606 (Homo sapiens) [Search protein sequence]
GAPATVTEQGEDITSKKDRGVLKIVKRVGNGEETPMIGDKVYVHYKGKLS
NGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEIAHLLIKPEYA
YGSAGSLPKIPSNATLFFEIELLDFKGE
3D structure
PDB9eu8 1,4-Pyrazolyl-containing SAFit-analogues are selective FKBP51 inhibitors with improved ligand efficiency and drug-like profile.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.2.1.8: peptidylprolyl isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1H7B A Y57 K60 D68 F77 Q85 I87 W90 Y113 S118 K121 I122 F130 Y45 K48 D56 F65 Q73 I75 W78 Y101 S106 K109 I110 F118
External links
PDB RCSB:9eu8, PDBe:9eu8, PDBj:9eu8
PDBsum9eu8
PubMed38818693
UniProtQ13451|FKBP5_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP5 (Gene Name=FKBP5)

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